SEVERITY RELATED NEUROANATOMICAL AND SPONTANEOUS FUNCTIONAL ACTIVITY ALTERATION IN ADOLESCENTS WITH MAJOR DEPRESSIVE DISORDER

BackgroundMajor depressive disorder (MDD) is a disabling and severe psychiatric disorder with a high rate of prevalence, and adolescence is one of the most probable periods for the first onset.The neurobiological mechanism underlying the adolescent MDD remains unexplored.MethodsIn this study, we examined the cortical and subcortical alterations of

Genes required for infection of mice by Salmonella Typhimurium can be identified by the interrogation of random transposon mutant libraries for mutants Certificate Holders that cannot survive in vivo.Inactivation of such genes produces attenuated S.Typhimurium strains that have potential for use as live attenuated vaccines.A quantitative screen, Tr